The HBO series picked up 12 total Emmys this season -- nine awards in technical categories and three top prizes at the glitzy ceremony in downtown Los Angeles -- television's equivalent of the Oscars.
The blood-spattered saga about noble families vying for control of the Iron Throne took home the most coveted prize of the night, the best drama Emmy -- along with statuettes for writing and directing.
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That gives it a total haul over the years of 38 -- more than any other narrative series since the first Television Academy prize-giving in 1949, overtaking the haul of 37 won by long-running comedy Frasier.
It went down to the wire in the end, as Thrones drew a blank in the acting categories, despite being a hot favorite and having multiple nominees, and only set the record with the last prize of the night.
No surprises: 'Game of Thrones' leads Emmy nominations
Three of its stars -- Lena Headey, Emilia Clarke and Maisie Williams -- dominated the betting in the supporting actress category, but the statuette went to Maggie Smith of Downton Abbey.
Peter Dinklage missed out on a supporting actor trophy, as did co-star Kit Harington, the category's favorite, with Ben Mendelsohn picking up the prize for Netflix family drama Bloodline.
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Here is a list of the winners in key categories for the 68th Emmy Awards.
OUTSTANDING DRAMA SERIES: Game of Thrones
OUTSTANDING COMEDY SERIES: Veep
BEST LEAD ACTOR, DRAMA: Rami Malek, Mr. Robot
BEST LEAD ACTRESS, DRAMA: Tatiana Maslany, Orphan Black
BEST LEAD ACTOR, COMEDY: Jeffrey Tambor, Transparent
BEST LEAD ACTRESS, COMEDY: Julia Louis-Dreyfus, Veep
BEST SUPPORTING ACTOR, DRAMA: Ben Mendelsohn, Bloodline
BEST SUPPORTING ACTRESS, DRAMA: Maggie Smith, Downton Abbey
BEST SUPPORTING ACTOR, COMEDY: Louie Anderson, Baskets
BEST SUPPORTING ACTRESS, COMEDY: Kate McKinnon, Saturday Night Live
OUTSTANDING TELEVISION MOVIE: Sherlock: The Abominable Bride
OUTSTANDING REALITY COMPETITION PROGRAM: The Voice
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