"The United States strongly condemns yesterday's heinous attack," State Department spokesman Mark Toner said in a statement.
Fresh tragedy: Child bomber kills 51 wedding guests in Turkey
"We extend heartfelt condolences to the friends and families of the victims and we wish a full and speedy recovery for the many who were wounded," he added.
"We stand by our ally and partner Turkey and reaffirm our commitment to defeating the common threat of terrorism."
Turkish President Recep Tayyip Erdogan has said that a child as young as 12 carried out Saturday's attack at a wedding in the town of Gaziantep near the Syrian border, probably for the Islamic State group.
A spokesman for the National Security Council, based in the White House, condemned the attack "in the strongest possible terms."
Turkey's Erdogan says IS 'likely perpetrator' of Gaziantep attack
"The perpetrators of this barbaric act cynically and cowardly targeted a wedding, killing dozens and leaving scores wounded," NSC spokesman Ned Price said.
"We are in close touch with Turkish authorities, and Vice President Biden will visit Ankara on Wednesday, August 24 to reaffirm our commitment to work together with Turkey, our valued NATO Ally and partner, to confront the scourge of terrorism."
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