"F.C. Internazionale Milano confirms that it has parted company with head coach Roberto Mancini by mutual agreement," the club said in a statement.
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Mancini is tipped in the media to be replaced by Dutch coach Frank de Boer.
Corriere dello Sport and Gazzetta dello Sport earlier reported that there was a contract dispute with Mancini and that the Chinese owners, who were furious after Inter lost 6-1 to Tottenham Hotspur in a friendly in Oslo on Thursday.
The former Manchester City boss had been coach for two years of the Milan based club, and was under contract until 2017.
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He was given severance pay of €2.5 million net, and will take his entire staff with him, Corriere dello Sport said.
De Boer left Ajax Amsterdam at the end of last season.
"Inter would like to place on record its thanks to Roberto for the work carried out with the team since joining in November 2014," the club said.
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