"The website in question was created in 2012 and has been removed because it does not accurately reflect my current business and professional interests," the mother of one tweeted Thursday.
US Republicans nominate Donald Trump for president
The website disappeared after US media questioned whether the wife of the Republican nominee for president had a degree in architecture from the University of Ljubljana in Slovenia, as the online biography stated.
Trump told MSNBC in February only that she "studied" design and architecture. A follow-up interview with GQ Magazine published in April said she dropped out after a year to pursue a modeling career in Milan and later Paris.
Those who try to access www.melaniatrump.com are now automatically diverted to her husband's company website.
Trump introduces wife Melania at Republican convention
While his three adult children, who hold executive positions at The Trump Organisation, have biographies on the site, she does not. Neither is she mentioned in her husband's more than 4,000-word online biography.
Thursday's tweet was a rare update from Melania Trump in the 13 months since her husband launched his controversial bid for the White House.
While the ex-model used to post regular style, food and scenic photographs, she has tweeted rarely since his foray into politics.
Last week, a staffer apologised for cribbing remarks from the current Democratic first lady for a speech Melania Trump delivered at the Republican National Convention in Cleveland, Ohio.
Plagiarism row tarnishes Melania Trump’s first address to the American public
Melania Trump had "always liked" Michelle Obama and read out passages from one of her speeches as examples of what she wanted to say, said the staffer.
"I did not check Mrs Obama's speeches. This was my mistake, and I feel terrible for the chaos I have caused," she said.
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