Pakistan 57-4 against England at 2nd day close
Chris Woakes took three for 18 in six overs before Shan Masood (30 not out) and Pakistan captain Misbah-ul-Haq (one not out) got through to the close.
Earlier, Joe Root made 254 as he became just the fourth England batsman after Denis Compton (278, Nottingham 1954) Ted Dexter (205, Karachi 1962) and current captain Alastair Cook (263, Abu Dhabi 2015) to score a double century against Pakistan in a Test match.
Three Pakistan bowlers conceded more than 100 runs each with leg-spinner Yasir Shah taking one for 213 in 54 overs.
Pakistan lead the four-match series 1-0 after their 75-run win in the first Test at Lord's last week.
Earlier, England captain Alastair Cook declared his side's first innings on 589 for eight after tea on the second day of the second Test against Pakistan at Old Trafford on Saturday.
Joe Root top-scored with a Test-best 254, with opener Cook making 105 as extended his own record for most Test centuries by an England batsman to 29.
The innings ended when Jonny Bairstow holed out for 58.
Wahab Riaz took three for 106 in 26.2 overs.
The left-arm quick was one of three Pakistan bowlers who conceded more than a hundred runs each.
Leg-spinner Yasir Shah, who took a match-winning 10 for 141 as Pakistan went 1-0 up in the four-match series with a 75-run win at Lord's last week, finished the innings with figures of one for 213 in 54 overs.
Earlier, on day one of the Test England captain Alastair Cook scored a hundred as well.
England are in complete control of the match with six wickets lost and the first innings total nearing 500.
On a batsmen's haven at Old Trafford, Root's first partner on day two Chris Woakes was dismissed by Yasir Shah.
Woakes punched a straight delivery into Yasir's hands to allow returning all-rounder Ben Stokes to walk in and join Root.
Stokes (34) was then dismissed by Wahab Riaz as a faint edge carried off his glove to the keeper.
Root, Woakes start day two
Pakistan faced a stern England batting side on day one in the second Test of the four-match series as hosts' captain Alastair Cook and Joe Root scored centuries at Old Trafford on Friday.
Pakistan were able to send four England batsmen back to the pavillion courtesy left-arm pacers Mohammad Amir and Rahat Ali for a score of 314 —each bowler bagged a brace.
Centurions Cook and Root dazzle for England
However, England never looked worried as runs kept coming from all sides. Also, the hosts didn't look disturbed by leggie Yasir Shah's presence.
England will be looking to carry the momentum into day two and score 500+ runs, while Pakistan will be looking to get the remaining batsmen out as soon as possible.
As we wait for the second day to start, here are the highlights of the first day.
Shahzad, Umar unlikely for England ODIs, T20Is
Day started with Amir's magic
Cook's century
England captain's departure
Won’t panic if England lose second Test against Pakistan: Jonny Bairstow
James Vince's short stint
Root's ton
Rahat in action again
The complete package