The officers in Baton Rouge were responding to a call of shots fired when they were ambushed by at least one gunman, Mayor Kip Holden told NBC News.
A gunman was shot but his condition was not clear, a Louisiana State Police official told NBC.
A spokesperson for the East Baton Rouge Sheriff's Office said police and sheriff's deputies were involved in the shooting incident.
Obama to head to Dallas as shooting rocks US race relations
"Multiple officers from both agencies sustained injuries and were transported to local hospitals," he said in an email.
He said there were no firm numbers on the number hurt or the extent of injuries. While the scene of the shootings was contained, police warned residents to stay away from the area, near Airline Highway, which is a mile from the Baton Rouge Police Department headquarters, where dozens of protesters were arrested earlier this month.
Two nearby hospitals were on lockdown, CBS reported. Efforts to confirm the report were not immediately successful.
The reports come a week after a wave of protests against police violence in Baton Rouge and other cities after a 37-year-old African-American father of five was shot and killed at close quarters by law enforcement officers.
At one of the demonstrations in Dallas, a gunman opened fire on white officers assigned to the protest, killing five of them
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