"The terrorists started shooting towards security, which they responded to", leading to the deaths of a pair of suspects while the others "committed suicide by blowing themselves up with suicide belts", the ministry's spokesperson said in a statement.
Police had surrounded the suspects' hideout between the holy city of Makkah and Taif on Thursday morning when the shootout occurred.
#BREAKING: 4 wanted militants surrounded by security forces in Noman Valley, #Makkah Thursday died during siege. pic.twitter.com/1RbJftmhul
— Saudi Gazette (@Saudi_Gazette) May 5, 2016
A simultaneous raid occurred on a hideout in the Red Sea city of Jeddah, where two people were arrested, "and they are being investigated for their involvement in this cell", the spokesperson said.
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He added that the raids were part of surveillance and followup, "including to what happened in Bisha on Friday".
At that time, two suspects died in a shootout with security forces who foiled a car bombing in Bisha, southwestern Aseer region.
A third suspect, Iqab Mujab al-Otaibi, fled but was later arrested wearing an explosives belt, the ministry announced last Sunday.
According to the ministry, Otaibi allegedly took part in a deadly shooting at a Shia mosque in 2014 and a bombing that targeted security forces at a mosque in Aseer last year.
Both attacks were among several bombings and shootings claimed by the Islamic State group since late 2014 in Saudi Arabia.
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