Local TV station WBS said the home was a half-way house for people transitioning out of rehab or time in prison.
When fire crews arrived on the scene early on Monday, the house was consumed by fire, with flamed shooting through the roof, fire department spokesperson Cortez Stafford said.
Dubai police say New Year's hotel fire caused by short-circuit
He would not give a death toll, saying a search of the home is not yet complete. Crews are working carefully because the roof could collapse, he said.
WBS said the tragedy claimed five or six lives.
Baldia factory fire was an act of arson, says JIT report
All were adults and included at least one woman, the station said.
The cause of the fire was not immediately known.
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