"Twenty-nine people were killed and 47 wounded in a suicide car bomb attack targeting the main checkpoint north of Hilla," a police lieutenant said.
Pictures posted on social media showed vast destruction around the checkpoint, where cars are usually bumper-to-bumper at that time of day, queueing to be checked by security personnel.
Potent threat: IS bombers kill 12 policemen at Iraq’s military base
A doctor at Hilla hospital said at least 11 of the wounded were in a very serious condition.
The Islamic State group, which carries out nearly all such attacks, has not had fixed positions south of Baghdad since security forces and allied militias began their fightback against the militants in late 2014.
Car bombing kills 28 in Ankara
A March 2014 suicide bombing at a checkpoint on the outskirts of Hilla, 80 kilometres (50 miles) south of the capital, killed 50 people and wounded more than 150.
IS claims responsibility
The Islamic State group claimed responsibility for the suicide truck bomb blast.
In a statement posted on social media, IS named the bomber who detonated his explosives-laden truck at a checkpoint outside the city of Hilla as Abu Islam al-Ansari.
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