The incident, coming just days after dozens of people were killed or wounded in suicide attacks in the capital, Kabul, and the eastern province of Kunar, casts doubt on efforts to revive a stalled peace process with the Taliban.
7 dead in attack on Pakistan consulate in Jalalabad
A bomb in a car driven by one of the attackers was detonated near the Indian consulate, shattering doors and windows and destroying at least eight cars as explosions and gunfire rocked the area, witnesses said.
Security forces in armoured vehicles were seen moving to the scene, while civilians fled. But the four attackers were killed before being able to enter the consulate compound, said Attahullah Khugyani, a spokesperson for the governor of Nangarhar province.
"Their target was the Indian consulate, but our forces shot and killed them all before they reached their target," he said.
The head of the public health department in Nangarhar, Najibullah Kamawal, said at least six people had been wounded in the attack.
Ghani assures stronger security measures for Pakistani diplomats in Afghanistan
There was no immediate claim of responsibility for the attack, which followed a suicide attack on the nearby Pakistani consulate in January.
That attack was claimed by Islamic State, which has a growing presence in Nangarhar, the province of which Jalalabad is the capital.
In January, India's consulate in the northern Afghan city of Mazar-i Sharif was also attacked by insurgents.
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