DiCaprio edged out Bryan Cranston (Trumbo), Matt Damon (The Martian), Michael Fassbender (Steve Jobs) and Eddie Redmayne (The Danish Girl) to take the best actor statuette.
DiCaprio won a standing ovation as he accepted the award -- one of the most highly anticipated moments of the night. He had been nominated six times in total, five of them for acting roles.
Sharmeen Obaid wins second Oscar award
The 41-year-old film veteran thanked a long list of figures who have helped him in his career, including Martin Scorsese, before speaking on his passion -- climate change.
"Climate change is real. It is happening right now. It is the most urgent threat facing our entire species and we need to work together and stop procrastinating," he said to applause.
"We need to support leaders around the world who do not speak for the big polluters, the big corporations, but who speak for all of humanity, for the indigenous people of the world," he said.
Twitter had a lot to say about his win.
https://twitter.com/vklays/status/704173116960985088
https://twitter.com/HilariousTed/status/704172993853923328
https://twitter.com/thebestofmarvel/status/704172841785286656
https://twitter.com/Batmancanseeyou/status/704172807882584065
Al Pacino won his first #Oscars for acting, after seven nominations.
— Mohandas Menon (@mohanstatsman) February 29, 2016
Leonardo DiCaprio in #Oscars2016 won his first, after four nominations
https://twitter.com/ChantelNicole44/status/704172674390605825
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