United's travelling support sang their displeasure as the 2-1 loss on Thursday evening dented the team's best hope of returning to the Champions League next season.
FC Midtjylland in the dressing room after last night's 2-1 win against Manchester United. šš https://t.co/aQ9g1mHNMh
— Football Tweet ā½īØ (@Football__Tweet) February 19, 2016
Midtjylland were Danish champions last year but had won just one of their previous ten fixtures and not played a competitive match since December.
Van Gaal toasts Man Utd's FA Cup success
Van Gaal, whose team trail fourth-placed Manchester City by six points in the Premier League, had played up United's "positive" start to the year after they came through their first four games of 2016 undefeated.
But United have now recorded just two wins in six since they beat Liverpool on January 17, increasing the pressure on their manager once again.
'Sacked three times' Van Gaal faces Friday fright night
"The fans can criticise. They are disappointed, like we are," the Dutchman said when told what supporters had been singing.
"They can do because when you see the second half maybe they are right. We have to improve and then the fans shall support us again.
"With keeper David de Gea injuring a knee during the warm-up to join a lengthy casualty list that includes captain Wayne Rooney, Van Gaal cited injuries as a factor in the defeat.
"It is difficult to cope with such a list of injured players," he said.
Van Gaal braced for Derby duel in FA Cup
That defence did not go down well at home.
Columnists at the Manchester Evening News described the defeat as a "new low" and called for Van Gaal to be sacked, while many irate fans took to Twitter.
@ManUtd please please just sack van gaal he is the worst thing that has ever happened at united
— Jordan Grindley (@JordanGrindley) February 18, 2016
The level of @ManUtd 's uselessness is unmatched
— Nqaba ka Njonjela (@Sbuda_LD) February 18, 2016
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