Spokesperson Lu Kang said in a statement that Xi would visit the three Middle Eastern countries over five days from Tuesday.
The trip, Xi's first to the region as president, comes amid mounting tensions over the war in Syria and after protesters ransacked and burned the Saudi Embassy in Tehran over the execution of a Shia cleric.
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China depends on the Middle East for its oil supplies but has long taken a back seat in the region's diplomatic and other disputes, only recently beginning to expand its role, especially in the Syrian crisis.
"China is the biggest importer of Middle Eastern oil," Zhu Feng, professor at Peking University's School of International Studies, told AFP.
"So stability in the Middle East is what China would most like to see."
As China's economy has grown, its dependence on imported oil and natural gas has increased, making the Middle East a crucial part of China's strategy as it seeks to expand its influence through Xi's signature foreign policy initiative, One Belt One Road.
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The massive investment scheme aims to increase China's footprint from central Asia to Europe through the use of loans to build infrastructure and transport networks.
Touted as a revival of ancient Silk Road trade routes, the initiative underscores China's ambition to wield geopolitical power to match its economic might.
Earlier this week a Chinese diplomat urged "calm and restraint" between Saudi Arabia and Iran, but Xi's trip was most probably organised before the discord erupted between Iran and Saudi, Zhu said.
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"Clearly now there are tensions between Saudi Arabia and Iran, so he will be going there in the role of persuader... to persuade Arab countries to cooperate to combat IS," he said, referring to the Islamic State extremist group.
"China will try and do what it can, but it still won't play a main role."
In the past month, Beijing has hosted high-level members from both the Syrian regime and its opposition.
It has consistently urged a "political solution" to the crisis despite having four times vetoed UN Security Council measures aimed at addressing the conflict.
Last year, China helped broker a landmark nuclear deal with Iran, which has begun to emerge following years of international isolation.
Days after the signing of the historic framework agreement, Iran was approved as a founding member of the Beijing-backed Asian Infrastructure Bank (AIIB), which is expected to provide funding for One Belt One Road.
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