The attack took place as Shias gathered at the mosque to observe Muharram.
"At least 10 people were killed and 12 others were wounded after a suicide bomber blew himself up at a Shia mosque," provincial home minister Sarfraz Bugti told AFP.
Local administration official Mohammad Waseem confirmed the attack and death toll.
Rescue workers and law enforcers reached the site, and shifted the deceased and injured to nearby hospitals.
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Bugti said there were six children between 10 and 12 years old among the dead and that some women had also been killed.
He added that the death toll may rise.
Witness Bashir Khan told AFP the bomber was trying to get inside the mosque hall but was intercepted by security after which he blew himself up in the courtyard of the mosque where children were playing.
"There is blood spattered all over, pieces of human flesh and shoes are littered everywhere," Khan said.
"The people put the wounded in private cars and took them to other towns as there is no hospital here," he added.
Chalghri is a remote area lacking proper infrastructure.
“There are no ambulances to transport the victims to hospitals,” eyewitnesses said, adding the dead and injured were shifted via private vehicles.
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