The jury of seven men and five women found the producer guilty of criminal sexual acts in the first degree and rape in the third degree, a measure of vindication for the dozens of women who came out against the one-time all-powerful filmmaker.
However, the 67-year-old Oscar-winner who produced films including "Shakespeare In Love" was found not guilty of first-degree rape and predatory sexual assault charges that could have seen him jailed for life.
The Time's Up foundation, formed in the wake of the Weinstein case, hailed the verdict as marking "a new era of justice."
"Abusers everywhere and the powerful forces that protect them should be on notice: There's no going back," it said in a statement.
The limited win for #MeToo presents the most high-profile sex assault conviction in the United States since Bill Cosby was found guilty in 2018 of drugging and sexually assaulting a woman 15 years ago.
Harvey Weinstein's rape trial still struggles to reach agreement
The decision was announced in a packed New York courtroom where some 100 people had gathered. The defendant, who attended the trial hunched over a walker, was shielded from view by police officers.
More than 80 women have accused Weinstein of sexual misconduct since allegations against him ignited the #MeToo global reckoning against men abusing positions of power in October 2017.
But the jury considered charges related to just two: ex-actress Jessica Mann and former production assistant Mimi Haleyi, with many claims too old to prosecute.
One of the predatory sexual assault charges also included testimony from "The Sopranos" actress Annabella Sciorra, who said Weinstein raped her in her New York apartment in the winter of 1993-94.
Six women took the stand from the opening of testimony on January 22, to say they had been sexually assaulted by Weinstein.
Weinstein will be sentenced on March 11.
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