"We can confirm that British nationals were among those killed in today's horrific attacks in Sri Lanka," a Foreign and Commonwealth Office spokeswoman told AFP.
"Our staff are supporting the relatives of the victims and are continuing to work with the relevant authorities to obtain further information.
"We extend our deepest condolences to those who have lost loved ones and all those affected by this senseless tragedy."
The spokeswoman did not give a figure for the Britons killed, but a government ministry source said London was aware of at least five British fatalities.
A series of eight devastating bomb blasts ripped through high-end hotels and churches holding Easter services, killing more than 200 people, including dozens of foreigners.
James Dauris, Britain's High Commissioner to Sri Lanka, was attending an Easter Day church service in Colombo that was cut short by the attacks. He visited UK nationals in hospital in the capital and called the attacks "evil".
British Prime Minister Theresa May condemned the blasts, saying on Twitter: "The acts of violence against churches and hotels in Sri Lanka are truly appalling, and my deepest sympathies go out to all of those affected at this tragic time.
"We must stand together to make sure that no one should ever have to practise their faith in fear."
Pope condemns Sri Lanka Easter attacks as 'such cruel violence'
In her Easter message released just hours before the blasts, May -- the daughter of an Anglican vicar -- offered her support to Christians around the world who face "huge danger" because of their faith.
She said: "Churches have been attacked. Christians murdered. Families forced to flee their homes.
"That is why the government has launched a global review into the persecution of Christians.
"We must stand up for the right of everyone, no matter what their religion, to practise their faith in peace."
Britain's Foreign Secretary Jeremy Hunt also condemned the Sir Lanka blasts.
He tweeted: "I'm deeply shocked and saddened by the horrifying attacks on churches and hotels in Sri Lanka.
"To target those gathered for worship on Easter Sunday is particularly wicked."
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