"As recorded by the IACHR since the start of the repression against social protests, to date, 264 people have lost their lives and more than 1,800 have been injured," the commission's chief Paulo Abrao told reporters.
He was speaking at a meeting of the Organization of American States — of which the IACHR is part — about the situation in the violence-wracked Central American country, where protesters are seeking the ouster of President Daniel Ortega.
Nicaraguans fear return to civil war past
The rights body had previously given a toll of 212 dead, although local estimates recently put the toll at about 250.
The influential Roman Catholic church has been mediating between Ortega's government and the opposition to end the unrest, but the process has become bogged down amid continuing violence.
In the latest outburst, at least 14 people died in a weekend raid by a pro-government mob near the opposition bastion of Masaya, in the country's southwest.
Nicaraguans fear return to civil war past
The opposition is planning to crank up the pressure on Ortega starting on Thursday with an anti-government protest and general strike.
A former leftist guerrilla, Ortega will next week commemorate the 1979 popular uprising that brought him to power with an annual July 19 march due to start in Masaya.
Once the hero of left-wing revolutionaries, Ortega is now widely viewed as an oppressor.
Having lost a presidential vote in 1990, he was re-elected in 2007 but opponents have accused him — together with his wife Vice President Rosario Murillo — of establishing a dictatorship characterized by nepotism and brutal repression.
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