The meeting will be hosted by US Secretary of State Rex Tillerson.
Trump has vowed to make the fight against IS a priority and directed the Pentagon and other agencies in January to submit a plan for defeating the militant group. The militants have been losing ground in both Iraq and Syria, with three separate forces, backed by the United States, Turkey and Russia, advancing on the group's Syrian stronghold of Raqqa.
Sunni politician warns US of mounting civilian casualties in Mosul
The meeting is the first of the international coalition since Iraqi government forces, backed by the US-led international coalition, retook several Iraqi cities from IS last year and liberated eastern Mosul. While the militant group is overwhelmingly outnumbered by Iraqi forces, it has been using suicide car bombs and snipers to
defend its remaining strongholds.
Iraqi Prime Minister Haider al-Abadi, who met with Trump in Washington on Monday, said he had won assurances of more US support in the war against IS.
A White House statement after the meeting said both Trump and Abadi agreed that "terrorism cannot be defeated by military might alone," and the two leaders called for deepening commercial ties.
Discussions on Wednesday will also focus on how to help Mosul rebuild and ways to tackle Islamic State operations in Libya and elsewhere.
Iraq battles IS in Mosul, commander says resistance weakening
In Syria, the US-led coalition has been working with an alliance of Kurdish and Arab militias. Its current focus is to encircle and ultimately recapture Raqqa - Islamic State's base of operations in Syria.
Syrian President Bashar al-Assad, who is supported by Russia and Iran, has said he saw scope for cooperation with Trump, although he has dismissed the US-backed military campaign against Islamic State in Syria as "only a few raids."
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