The 22-year-old woman was returning on foot with her parents from a jungle safari in Chitwan National Park when the elephant charged at the group.
"She was immediately taken to a hospital but died while under treatment," Chitwan's police chief Deepak Thapa told AFP.
Bangladesh, India mount rescue for flood-hit elephant
"Her parents were not hurt."
Last month a woman was trampled to death and two others were injured when wild elephants rampaged through a village in the southern district of Bardia.
There are about 300 elephants in Nepal, mostly domesticated. They are used to take tourists on jungle rides and for anti-poaching patrols in the country's national parks.
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