The passenger coach was on its way from Karachi to Pishin when it overturned in Pir Umer area of the district, killing 25 people on the spot.
According to sources, the cause of the incident was tyre burst.
The deceased and injured were shifted to the district headquarters hospital.
On May 22, eight people were killed and 38 others injured when their speeding bus overturned in the Naag area of Panjgur.
Panjgur tragedy: Would-be groom among 8 dead as bus overturns
The deceased were identified as bridegroom Fahim, Waleed, Muzammil, Waqas, Muzaffar, Sanaullah, and a woman, Shararato, while identity of the eighth person could not be confirmed.
On the same day, 13 people also died and 16 others sustained injuries when a speeding truck collided with a passenger bus near Jhang district.
The deceased were identified as Muhammad Asif, Arshad, Bakhsheesh Ali, Muhammad Nauman, Muhammad Babar, Asghar Ali, Muhammad Azhar, Muhammad Akram, Sher Muhammad, Muhammad Kamran, Shakeel Ahmad, Hafiz Nazakat Ali and Sher Abbas.
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